Synovo offers a range of pharmacological support services that may form part of an integrated drug discovery project, or a stand-alone test.

 

  • Cell culture
  • Microbiology
  • PK/PD
  • Analytics
  • Formulation

 

Our pharmacological expertise centers mainly on disease models and pharmacokinetics. We provide a cost effectively way to obtain distribution and metabolism data early in discovery. This information allows informed decision making on the fate of a compound prior to significant investment. Furthermore, we offer the possibility of working with minimum amounts of compounds, avoiding therefore up-scaling manufacture processes in early stages of development.

 

Because Synovo has in-house chemistry facilities, pharmacology can be coupled with compound formulation, galenics and stability studies if necessary. These packages are competitively priced to allow their use early in discovery.

 

As part of its pharmacology activities, Synovo has  a cell biology team able to generate cell lines and support in assay design and screening projects. Team expertise focus on the construction of expression cassettes, expression of membrane proteins and the selection of high expressing cells. Cell line construction may be combined with fluorescent substrate design, assay design and electrophysiological characterization of membrane proteins.

 

Furthermore, Synovo’s microbiology team, mainly focus on biofilm studies, also collaborates in the pharmaceutical development.

 

Metabolites and markers easily determined in routine studies:

Assay/Analyte

Method

ALT/AST

Colorimetric

Alkaline phosphatase

UV

Bilirubin

Fluorescent./colorim./DAHPLC

Amino acids, SAM, glutamate etc.

LC-MS/MS

Bile acids

LC-MS/MS

Cholesterol

Colorimetric/fluorescence

Triglycerides

Colorimetric

Hormones

MS, ELISA

Sugars

Oxidases/direct

Peptides - e.g. Insulin

ELISA

Coagulation

Direct

Cytokines

ELISA

 

 

 

96 well plate_EV

 

 

 

 

 

 

Biofilm_II

 

 

 

Synovo GmbH
Paul Ehrlich Str. 15
D-72076 Tübingen
Germany
Tel +49 (0) 7071 964325
Fax +49 (0) 7071 964326
Mail contact@synovo.com
 
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