We are very proud about the most recent publication from our employee Mariella Martorelli, who successfully published her scientific work (Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors) in the Journal of Medicinal Chemistry.
As a potential therapeutic approach for neurodegenerative diseases (such as Alzheimer and Multiple Sclerosis), novel Skepinone-based p38α MAP kinase inhibitors were optimized to cross the blood-brain-barrier (BBB). In vitro screens were performed to establish their potency inhibiting pro-inflammatory cytokines (such as TNFα and IL-6) and their selectivity to the alpha isoform while in vivo PK studies were performed to select the drug being able to penetrate the BBB.
Read more here: Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.